Abstract: There are numerous techniques for microfabrication of patterned polymer surfaces and microchips for drug delivery. While silicon has been the choice material for much of the research done with MEMS, the methacrylates and acrylates provide a rapid and inexpensive base for future work. Cyclodextrins have been used for two purposes: as a solubilising agent of paclitaxel, which it is a very lipophilic compound, and for their ability to disturb and inhibit the activity of the intestinal P-gp. The oral bioavailability of these cyclodextrin-poly(anhydride) nanoparticles was about 80%. This fact would be due to the combination of both bioadhesive and inhibitory properties of these nanoparticles.
Keywords: Nanotechnology, Delivery, MTC, RNA