Abstract: Exhaled volatile organic compounds (VOCs) can be used to diagnose certain chronic conditions, however there is no data about how well they work to distinguish between individuals with congestive heart failure (CHF), particularly with older patients when Natriuretic peptides are less accurate [2]. The prognosis for heart failure (HF) is not good, and finding indicators of the disease's severity may aid in its management. In a pilot investigation, we found that HF patients' exhaled breath contained substantial amounts of acetone. The purpose of this study was to assess exhaled acetone as an indicator of heart failure diagnosis and heart failure severity [4]. We assessed the ability of VOCs evaluation to detect patients with or without CHF, classify the severity of CHF, and forecast how well decompensated CHF patients will respond to treatment. Procedures and Outcomes: In addition to 117 healthy controls and 103 controls with chronic obstructive pulmonary disease (COPD), we enrolled 89 participants who had been hospitalized to an intensive care ward with acutely decompensated CHF [2]. 89 patients (the HF group) who met the inclusion criteria were compared to age- and sex-matched healthy subjects out of the 235 patients with systolic dysfunction who were assessed between May 2009 and September 2010. Exhaled breath was collected from patients with heart failure (HF) who were categorized based on their clinical stability (acute decompensated HF [ADHF], n = 59; chronic HF, n = 30). Gas chromatography-mass spectrometry was used to identify the chemical species, and Spectrophotometry was used to quantify the results. Diabetic patients were not accepted [4]. Echocardiography was conducted by CHF patients. The Pneumo Pipe was used to gather the VOCs, and the BIONOTE electronic nose was used to evaluate them. A partial least squares analysis was assessed to assess the VOCs' ability to discriminate [2]. The accuracy of the CHF classification against the healthy and COPD controls was 81% and 69%, respectively; the accuracy remained unchanged in a sensitivity analysis that excluded participants who were 65 years of age or older, although therapy-induced weight changes were not predicted. Conclusions: VOC pattern corresponds with heart function markers and can distinguish elderly CHF patients from healthy individuals and COPD sufferers [2].
Keywords: Exhaled volatile organic compounds (VOCs), Congestive heart failure (CHF), Heart failure diagnosis, Exhaled breath acetone (EBA), Acutely decompensated heart failure (ADHF), Chronic heart failure (CHF), Gas chromatography-mass spectrometry (GC-MS), BIONOTE electronic nose, Pneumo Pipe VOC collection, Heart failure severity assessment, Natriuretic peptides (BNP), Heart function markers, COPD and heart failure differentiation, VOC biomarkers, Echocardiography in heart failure
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DOI:
10.17148/IJARCCE.2024.131116
