Abstract: A thorough characterization of the evolution process of solid tumors and the composition of circulating tumor DNA would greatly facilitate the development of therapeutic approaches. This work depicts the computational modeling approach towards unearthing the intricate relationship between spatial organization in solid tumors and the circulation tumor DNA. The study assesses how spatial organization makes a difference to the tumor cells' release into the blood flow, the incurred effect on mutational landscapes, and high resolution about the simulation of heterogeneity in circulating tumor DNA. The spatial confinement was found dramatically to affect tumor evolution and ctDNA molecular composition-very important for the design of precision medicine strategies, such as non-invasive biomarker detection and personalized therapeutic interventions. Results suggest that spatial tumor organization affects the timing of ctDNA release, and therefore could influence the sensitivity of liquid biopsy to early tumor tracking and treatment response. Integrate computational models with experimental and clinical data in order to validate predictions, refine understanding of ctDNA dynamics, and push the advance in oncology diagnostics, monitoring, and treatment toward better outcomes in personalized medicine.
Keywords: Evolution of solid tumor, Computational modeling, Comprehensive simulations, Circulating tumour DNA (ctDNA), Non-invasive diagnostics.
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DOI:
10.17148/IJARCCE.2025.14451
